Selected Publications

• Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology. Ling Xie, Ryan N. Sheehy, Adil Muneer, Yan Xiong, John A. Wrobel, Feng Zhang, Kwang Su Park, Julia Velez, Jing Liu, Yan Jia Luo, Brent Asrican, Ping Dong, Ya Dong Li, Corina Damian, Luis Quintanilla, Yongyi Li, Chongchong Xu, Mohanish Deshmukh, Leon G. Coleman, Guo Li Ming, Hongjun Song, Zhexing Wen, Jian Jin, Juan Song, Xian Chen. Nature Communications
• The structural diversity of psychedelic drug actions revealed. Ryan H. Gumpper, Manish K. Jain, Kuglae Kim, Renhong Sun, Ning Sun, Zhongli Xu, Jeffrey F. DiBerto, Brian E. Krumm, Nicholas J. Kapolka, H. Ümit Kaniskan, David E. Nichols, Jian Jin, Jonathan F. Fay, Bryan L. Roth. Nature Communications
• Discovery of the first-in-class DOT1L PROTAC degrader. Hyerin Yim, Renhong Sun, Zhongli Xu, Huen Suk Kim, Minjeong Kim, Tao Cao, Ling Xie, Xian Chen, H. Ümit Kaniskan, Jian Jin. European Journal of Medicinal Chemistry